Through the years, the seismic resistance of underground structures has attracted more and more attention, and dynamic characteristics of metro station is one of the most important issues. In this article, the 3D numerical model of Zhang Wangqu metro station along Metro Line 5 in Xi'an is established to study on seismic dynamic response of roof, floor, columns and beams in the island platform metro station. Compared with the earthquake damage of Dakai metro station in the Kobe M7.2 Earthquake and the shaking table test of metro station in loess area, results reveal that horizontal acceleration can reflect seismic wave characteristics under the horizontal seismic wave; the maximum relative displacement of roof and floor, the maximum axle force and shear force at transfer node are bigger than the standard section and reduce with the increase of buried depth; the maximum axle force and shear force of columns increases from top to bottom. The island platform metro station should focus on the structural settings of transfer node, and the columns and beams here must select materials with greater strength.