The high-rise frame-diagrid structure is a new type of dual system structure. The inner frame part can create a large space, and the external diagrid part can provide a larger lateral stiffness. In this paper, the lateral deformation formula for the high-rise frame-diagrid structures is derived. The bending deformation of the structure is divided into the bending rotational deformation and the floor rigid rotational deformation. The physical storey drift is proposed. The physical storey drift is directly related to the structural damage. When the structure is in the plastic state, the structure maximum storey drift and maximum physical storey drift are in different positions. It is recommended to use both storey drift and physical storey drift as structural deformation limitation criteria. Finally, the proposed method is used to structural parameters analysis for the high-rise frame-diagrid structure. It provides reference for the structural design.