With the implementation of “The Belt and Road” policy and increasing investment, there will be a large number of large-scaled construction projects (LSCP) in China. However, the comprehensive benefit of most LSCP is not satisfactory because of concerning more about the economic benefits. It makes the sustainability of LSCP concerned about. In order to ensure the sustainable development, the evaluation of the comprehensive benefit of LSCP should be carried out. Based on comprehensive literature review and content analysis, 30 influence factors of comprehensive benefit evaluation for LSCP are identified. The evaluation index system of 17 factors containing three subsystems of social, economic and environmental benefit is established through factor analysis. Entropy method is used to determine weights of each indicator, and then synthetic evaluation model is put up. This paper selects a practical case, Lieder Village reconstruction in Guangzhou, to calculate the synthetic evaluation value using fuzzy theory. The evaluation results are satisfactory and in line with reality. It shows that the evaluation index system and synthetic evaluation model has a certain reference value for analysis of comprehensive benefit and can help for enhancing the construction and management level of LSCP and promoting the sustainable development of LSCP.